What is Palmitoylethanolamide?
Palmitoylethanolamide (PEA) essentially is known to belong from the family of or part of the endocannabinoid familyand is also a member of N-acylethanolamines. NAEs are released from cells in response to noxious stimuli. As almost all NAEs, also the PEA has a local effect, and its tissue levels are closely regulated through the balance of production and degradation activity.
Two intracellular amidase enzymes that are expressed in the inflammatory cells have been involved in lipid amide degradation: fatty-acid amide hydrolase (FAAH) and N-acylethanolaminehydrolyzing acid amidase (NAAA). It is a group of fatty acids or endogenous fatty amide that classifies as nuclear factor agonists. Some of these primary reports prove that it is anti-inflammatory in the property as well as an analgesic. The palmitoylethanolamide supplement has been used in several cases to relieve chronic pain in most adult patients that have some kind of underlying health issues.
Palmitoylethanolamide and its uses
Apart from relieving pains palmitoylethanolamide supplement is used to reduce carpal tunnel syndrome, infections of the airway, neuropathic pain, fibromyalgia, multiple sclerosis (MS), and among many other conditions, but there is no good scientific evidence to support these facts about Palmitoylethanolamide.
For instance, Palmitoylethanolamide can used to treat low back pain. Also to avoid any kind of adverse effects while treating adult patients with a chronic illness is allowed to take the Palmitoylethanolamide supplement to ease and relieve pain such as chronic pelvic pain, that cannot be taken care of just by injecting local analgesic as the effects may vary from patient to patient.
How long does it take for Palmitoylethanolamide and its history
In the year 1957, Palmitoylethanolamide was discovered and if reports are to be believed then until the end of 1980, this palmitoylethanolamide supplement was used as analgesics and anti-inflammatory drugs. In theearly-mid1990s, the relationship between anandamide and PEA was described as the expression of mast cell receptors sensitive to the two molecules which was demonstrated by Levi-Montalcini and his coworkers. If Primary reports are to be believed then, it is quite evident that Palmitoylethanolamide regulates as hyperactive mast cells depending on the dosage.
However, when it comes to working with PEA or Palmitoylethanolamide on a person, it takes about two months to show visible results. It sometimes depends on how a person’s body reciprocates to this drug and may take a longer time to heal. Palmitoylethanolamide forms a hormone functioning enzyme in the patient’s body and regulates as a neurotransmitter that results in attentive and task completion behavior.
Are there any side effects caused by Palmitoylethanolamide?
There is a possibility that if palmitoylethanolamide supplement like pyrroloquinoline quinone (pqq) has benefits then it also might have side effects. Unfortunately, this drug can cause side effects if consumed by mouth for longer periods such as agitation, rapid heartbeat, palpitations, anxiety, the heaviness of stomach, gastrointestinal issues, diarrhea, etc. Contradictory to that, unlike, other stimulant drugs that are endogenous to the brain, PEA is considered to be non-addictive.